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EC number: 222-048-3
CAS number: 3327-22-8
There were no significant treatment related differences between the test substance and control group animals. No treatment related changes in
food consumption were noted, but there were occasional statistically significant changes in the high dose males, which consumed more food in
10/11, 25/26, and 97/98. During week 49/50, these animals had slightly lower food consumption. The low dose group had slightly lower
food consumption in week 65/66. The high dose females had marginally higher food consumption in weeks 3/4, 11/12, 13/14, 65/66 to 73/74. Low
females had slightly increased food consumption in weeks 3/4, 11/12 and 81/82. The overall food consumption was 3.3% higher in low dose
and 6.6 in high dose females. These changes were considered to reflect biological variation since they were marginal, less than 10 %
overall. No treatment related body weight changes were observed during the study. The body weight of low dose males was slightly higher during
weeks 11 to 21
(max. 6.5 %) 57, to 61 (5.0 %) and in the week 73 (6.1 %). The body weight of low and high dose females was slightly higher in
week 65 (7.4 % in low and 7.7% in high dose). In the pathological examination, a small but statistically significant decrease of left testis absolute
(0.223 g control, 0.214 g low dose (-4%) and 0.192 g high dose (-14%)) and organ weight relative to body weight (0.488 control, 0.477 (-2%) low
dose and 0.414 high dose (-15%)) was seen in the high dose male mice. The female mice of the high dose group had an increased absolute
and relative weight of the liver and adrenals. The absolute weight of the right kidney was increased in the high dose females. In histopathology, the
microscopical examination revealed a slight dose-related increase in the incidence of minimal to mild focal acanthosis and hyperkeratosis at the
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