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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study witha acceptable restrictions.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report Date:
1986

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: Quab 188, 65.4 % aqueous solution

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
2 mLkg bw 65% CHPTAC (1174 mg/mL for 65% CHPTAC) = 2348 mg/kg bw
No. of animals per sex per dose:
5

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 348 mg/kg bw
Remarks on result:
other: 65% CHPTAC
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 526 mg/kg bw
Remarks on result:
other: for 100% CHPTAC (according to RAR, 2008).

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The dermal LD50 value was found to be greater than 2348 mg/kg bw which corresponds to 1526 mg/kg of pure CHPTAC.
Executive summary:

A limit test was conducted to assess the dermal toxicity of the test substance (65% CHPTAC). Under the experimental conditions the dermal LD50 value was found to be greater than 2348 mg/kg which corresponds to 1526 mg/kg of pure CHPTAC.