Registration Dossier
Registration Dossier
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EC number: 222-048-3 | CAS number: 3327-22-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
- Objective of study:
- absorption
- Principles of method if other than guideline:
- Method: other: Draft OECD Guideline 428 skin absorption in vitro method
- GLP compliance:
- yes
Test material
- Reference substance name:
- (3-chloro-2-hydroxypropyl)trimethylammonium chloride
- EC Number:
- 222-048-3
- EC Name:
- (3-chloro-2-hydroxypropyl)trimethylammonium chloride
- Cas Number:
- 3327-22-8
- Molecular formula:
- C6H15ClNO.Cl
- IUPAC Name:
- 3-chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- 48 hour(s)
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parametersopen allclose all
- Toxicokinetic parameters:
- half-life 1st:
- Toxicokinetic parameters:
- half-life 2nd:
- Toxicokinetic parameters:
- half-life 3rd:
Any other information on results incl. tables
Concentration: 65%, dose 7028 µg/cm2
Flux constant [µg cm-2 h-1]: 18.5 ± 13.0
Kp-value [cm h-1]: 0.026 ± 0.018
Lag time [h]: 0.1 ± 0.2
Relative skin absorption after 48 h: 13.9%
Concentration: 20%, dose 1966 µg/cm2
Flux constant [µg cm-2 h-1]: 21.0 ± 13.6
Kp-value [cm h-1]: 0.107 ± 0.069 Lag time [h]: 0.2 ± 0.4
Relative skin absorption after 48 h: 40.9%
Concentration: 1%, dose 94.6 µg/cm2
Flux constant [µg cm-2 h-1]: 0.61 ± 0.7
Kp-value [cm h-1]: 0.065 ± 0.074
Lag time [h]: 1.8 ± 0.4
Relative skin absorption after 48 h: 22.6%
Concentration: 0.1%, dose 9.73 µg/cm2
Flux constant [µg cm-2 h-1]: 0.15 ± 0.12
Kp-value [cm h-1]: 0.151 ± 0.128
Lag time [h]: 1.3 ± 0.6
Relative skin absorption after 48 h: 43.6%
The amount of radioactivity on the skin after stripping was 5.3 to 17.6-fold lower than the amount of radioactivity in the receptor fluid. The mean recovery of radioactivity was between 91.2 and 102.2 %.
Applicant's summary and conclusion
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