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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1997-12-09 to 1998-01-15
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Reference:
Composition 0
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
Directive 92/69/EEC, A.8.
Deviations:
no
GLP compliance:
yes
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Test material information:
Composition 1
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
< -1.5
Temp.:
25 °C
pH:
3.9
Details on results:
The partition coefficient (1-octanol/buffered water phase, pH4) of the test item was calculated as mean value from all single results. The pH value of the buffer solution was 3.95.

Test No. (O/W)

concentration of test substance in the 1-octanol phase [mg/l]

concentration of test substance in the 1-octanol phase [mg/l]

Pow

mean value

Pow

pH-value of aqueous phase

A (1/3)

 <50

 1615.8758

 <0.03094

 <0.03095

3.92

B (1/3)

 <50

 1614.7795

 <0.03096

3.95

C (1/1)

 <50

 1583.8554

 <0.03157

 <0.03129

3.95

D (1/1)

 <50

 1612.8268

<0.03099

3.94

E (3/1)

 <50

 1634.4181

 <0.03059

 <0.03079

3.95

F (3/1)

 <50

 1613.6414

 <0.03099

3.95

Blank(1/1)

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3.94

Conclusions:
A log Pow value of lower than -1.5 was determined at pH 3.9 and 25°C in a reliable study conducted according to EU method A.8.
Executive summary:

The partition coefficient octanol/water of the test item was determined according to EU method A.8 and is < 1.5 at pH 3.9 and 25 °C.

Description of key information

The log Pow of the test item is < -1.5 at pH 3.9 and 25 °C.

Key value for chemical safety assessment

Log Kow (Log Pow):
-1.5
at the temperature of:
25 °C

Additional information

The partition coefficient octanol/water of the test item was determined according to EU method A.8.