Registration Dossier
Registration Dossier
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EC number: 247-761-7 | CAS number: 26530-20-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-octyl-2H-isothiazol-3-one
- EC Number:
- 247-761-7
- EC Name:
- 2-octyl-2H-isothiazol-3-one
- Cas Number:
- 26530-20-1
- Molecular formula:
- C11H19NOS
- IUPAC Name:
- 2-octyl-2H-isothiazol-3-one
- Reference substance name:
- dihydrogen oxide
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- dihydrogen oxide
- Test material form:
- liquid
Constituent 1
impurity 1
Method
Species / strain
- Species / strain / cell type:
- other: S. typhimurium TA 97/98/100/1535/1537/1538
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
Results and discussion
Test results
- Key result
- Species / strain:
- other: S. Typhimurium TA 97/98/100/1535/1537/1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
