Registration Dossier
Registration Dossier
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EC number: 606-948-7 | CAS number: 2217-02-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance material review on fenchyl alcohol
- Author:
- Bhatia S P
- Year:
- 2 008
- Bibliographic source:
- Food and Chemical Toxicology, 46 (2008), pp 157-159
Materials and methods
- Principles of method if other than guideline:
- No data on test method
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- 3,3-dimethyl-8,9-dinorbornan-2-ol
- EC Number:
- 216-639-5
- EC Name:
- 3,3-dimethyl-8,9-dinorbornan-2-ol
- Cas Number:
- 1632-73-1
- Molecular formula:
- C10H18O
- IUPAC Name:
- 1,3,3-trimethylbicyclo[2.2.1]heptan-2-ol
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths ocurred.
- Clinical signs:
- other: Not specified
- Gross pathology:
- Not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified (CLP Regulation EC no. 1272/2008)
- Conclusions:
- The acute dermal LD50 value of the test substance was >2000 mg/kg bw in guinea pigs.
- Executive summary:
The acute dermal toxicity of Fenchol was evaluated in 2 guinea pigs. Test substance was administered via dermal application at 2000 mg/kg/body weight. The animals were observed for 14 days. No deaths occurred. Thus, the acute dermal LD50 value of the test item was determined to be greater than 2000 mg/kg bw.
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