Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The substance is predicted to have a LD50 of ca. 2231 mg/kg bw. However, the prediction is deemed to be reliable with restrictions as the substance could be out of the applicability domain of the model.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, and documentation / justification is limited
Qualifier:
equivalent or similar to guideline
Guideline:
other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
Species:
rat
Statistics:
The applicability domain of predictions is assessed considering:

- Similar molecules with known experimental value.
- Accuracy of prediction for similar molecules.
- Concordance for similar molecules.
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 2 231 mg/kg bw
Remarks on result:
other: Result by Consensus method.

The result appears reliable with restrictions as the predicted compound could be out of the applicability domain of the model.

Interpretation of results:
GHS criteria not met
Conclusions:
The substance has a LD50 of ca. 2231 mg/kg bw.
Endpoint conclusion
Dose descriptor:
LD50
Value:
2 231 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

Overall, data available are judged as inconclusive for classification.