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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance Raw Material Monograph: d-Carvone
Author:
Edited by:D. L. J. Opdyke
Year:
1978
Bibliographic source:
Food and Cosmetics Toxicology, Volume 16, Supplement 1, 1978, Pages 673-674
Reference Type:
review article or handbook
Title:
Toxicology and Carcinogenesis Studies of d-Carvone (CAS No. 2244-16-8) in B6C3F1 Mice (Gavage Studies)
Author:
U.S. National Toxicology Program (NTP)
Year:
1990
Bibliographic source:
Toxicology and Carcinogenesis Studies of d-Carvone (CAS No. 2244-16-8) in B6C3F1 Mice (Gavage Studies),NTP TR 381, (Report Date: 1990)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the dermal irritation potential of d-carvone in humans
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
(S)-2-methyl-5-(1-methylvinyl)cyclohex-2-en-1-one
EC Number:
218-827-2
EC Name:
(S)-2-methyl-5-(1-methylvinyl)cyclohex-2-en-1-one
Cas Number:
2244-16-8
Molecular formula:
C10H14O
IUPAC Name:
5-isopropenyl-2-methylcyclohex-2-en-1-one
Test material form:
liquid
Details on test material:
- Name of test material: d-Carvone- IUPAC name: (5S)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one- Molecular formula: C10H14O- Molecular weight: 150.22 g/mole- Smiles :C1[C@H](CC=C(C1=O)C)C(C)=C- Inchl: 1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3/t9-/m0/s1- Substance type: Organic- Physical state: Colorless
Specific details on test material used for the study:
- Name of test material: d-Carvone- IUPAC name: (5S)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one- Molecular formula: C10H14O- Molecular Weight: 150.22 g/mole- Smiles Notation: C1[C@H](CC=C(C1=O)C)C(C)=C- Inchl: 1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3/t9-/m0/s1- Substance type: Organic- Physical state: Colorless to pale-yellow liquid

Test animals

Species:
other: humans
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: petrolatum
Controls:
not specified
Amount / concentration applied:
2% in petrolatum
Duration of treatment / exposure:
48 hours
Observation period:
48 hours
Number of animals:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
no signs of irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
d-carvone was not irritating to humans after 48 hours exposure.
Executive summary:

A skin irritation study was performed in humans to assess the irritation potential of d-carvone. d-carvone was tested 2% in petrolatum human volunteers in a 48 hours closed patch test. d-carvone was not irritating to humans after 48 hours exposure.