Registration Dossier
Registration Dossier
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EC number: 218-827-2 | CAS number: 2244-16-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer-reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of 2244-16-8 (d-carvone) in rats
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2017
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity study of d-Carvone (2244-16-8) in rat
- Author:
- Richard J. Lewis
- Year:
- 2 012
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set,2012
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study of d-Carvone (2244-16-8) in rats
- Author:
- RTECS
- Year:
- 2 017
- Bibliographic source:
- RTECS (registry of toxic effect of chemical substance data base ), 2017
- Reference Type:
- review article or handbook
- Title:
- SAFETY EVALUATION OF CERTAIN FOOD ADDITIVES(WHO FOOD ADDITIVES SERIES: 42)
- Author:
- World Health Organization
- Year:
- 1 999
- Bibliographic source:
- the Fifty-first meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), WHO FOOD ADDITIVES SERIES: 42,1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity test was carried out to study the effects of d-Carvone (2244-16-8) on rats.
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
Test material
- Reference substance name:
- (S)-2-methyl-5-(1-methylvinyl)cyclohex-2-en-1-one
- EC Number:
- 218-827-2
- EC Name:
- (S)-2-methyl-5-(1-methylvinyl)cyclohex-2-en-1-one
- Cas Number:
- 2244-16-8
- Molecular formula:
- C10H14O
- IUPAC Name:
- 5-isopropenyl-2-methylcyclohex-2-en-1-one
- Details on test material:
- - Name of test material (IUPAC name): (5S)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one- Common name: d-Carvone- Molecular formula: C10H14O- Molecular weight: 150.22 g/mol- Smiles notation: C1[C@H](CC=C(C1=O)C)C(C)=C- InChl: 1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3/t9-/m0/s1- Substance type: Organic
1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):d-Carvone- Molecular formula :C10H14O- Molecular weight :150.22 g/mol- Substance type:organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 3710 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 710 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at dose 3710 mg/kg bw in treated rats
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be 3710 mg/kg bw,when rats were treated with d-Carvone (2244-16-8) orally.
- Executive summary:
Acute oral toxicity study was done in rats using test materiald-Carvone(2244-16-8).50% Mortality was observed at dose 3710 mg/kg bw. Hence,LD50 value was considered to be 3710 mg/kg bw,when rats were treated with d-Carvone(2244-16-8) orally.
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