Registration Dossier
Registration Dossier
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EC number: 614-626-2 | CAS number: 685853-81-0
Endpoint summary
Administrative data
Description of key information
Regardless of the high Cr3+ doses, chromium(III) oxide did not cause any significant treatment-related changes in the general condition of animals, body weights, clinical biochemistry, haematology, or pathological examination.
Citric acid and associated salts are found in many foods and are formed in cells as a metabolite from glycolysis. There is no toxicity theshold for repeated exposure in humans, although acute toxic effects have been reported in animals.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 200 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Confirmed in CICAD Review document (UN Concise International Chemical Assessment Document 76 )
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEC
- 44 000 mg/m³
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Confirmed in CICAD Review document (UN Concise International Chemical Assessment Document 76 )
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 44 000 mg/m³
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Confirmed in CICAD Review document (UN Concise International Chemical Assessment Document 76 )
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
