Registration Dossier
Registration Dossier
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EC number: 205-581-6 | CAS number: 143-06-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
OECD 422: 50 mg/Kg bw/day was determined to be the NOAEL (No Observed Adverse Effect Level) for systemic and developmental toxicity in rats.
Effect on fertility: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 50 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- One key Guideline (OECD 422) combined repeated dose, reproductive developmental toxicity screening study in rats available for assessment.
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Effects on developmental toxicity
Description of key information
Dose range-finding pre-natal developmental toxicity: The test material exhibited maternal toxicity when administered at 1000 mg/Kg/day while it was well tolerated when administered to pregnant rats for 14 days (Days 6-19 post coitum), up to the dose level of 100 mg/Kg/day.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- One key pre-natal developmental toxicity dose range-finding study in rats available for assessment.
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available information derived from the experimantal study conducteed on the substance. No classification is warranted according to the CLP Regulation (EC n. 1272/2008).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
