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Diss Factsheets
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EC number: 615-064-0 | CAS number: 700874-87-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- ADDITIONAL INFORMATION SUPPORTING DATA WAIVING
At the required tonnage band of registration, the following information are required to be provided: Adsorption/desorption screening test. The OECD Test Guideline 121 and EU method C.19. “Adsorption/desorption screening test “ describe an experimental method using HPLC for the estimation of the adsorption coefficient Koc in soil and in sewage sludge. The test substance is injected in the column packed with cyanopropyl solid phase containing lipophilic and polar moieties. As a result of partitioning between mobile and stationary phases the test substance is retarded and the Koc is determined basing on the retention time of the substance. The Adsorption/desorption screening test according to OECD Test Guideline 121 is not technically applicable to MOVE 3. In fact, the method described in the mentioned test guidelines is based on the same principle as the OECD Test Guideline No. 117 “Partition Coefficient (n-octanol/water), HPLC Method”. The HPLC method was tried to be used for the determination of Kow according to the OECD guideline No. 117. The method was tested but proved not applicable since MOVE3 is not detected using UV detection at 210 nm, Refractive Index detection, Evaporative Light Scattering detection or Mass Spectrometric detection. For this reason the Adsorption/desorption screening test is not technically feasible for MOVE 3. It should be noted that also the feasibility of the adsorption/desorption measurement according to the batch equilibrium method (OECD Test Guideline No. 106 and EU method C.18), that according to REACH Annexes IX may be required for the higher tonnage band of registration, is questionable. In fact high volatilization of the substance from water was observed, and this is expected to prevent the achievement of a stable concentration in water during the test. Moreover analytical issues may occur during the quantification of MOVE 3 concentration in water. In fact, analytical difficulties were observed when the analytical method for quantification in water was tried to be applied in ecotoxicological test. The analytical difficulties observed in the ecotoxicological study were ascribed to the MOVE 3 physical and chemical properties (poorly soluble, extremely volatile liquid with a boiling point of 19.5°C) and since all the feasible measures for improving the analytical performance were applied unsuccesfully the test was considered technically unfeasible. As the adsorption/desorption measurement according to the batch equilibrium method (OECD Test Guideline No. 106 and EU method C.18) requires several analytical measurements in water the same analytical issues observed in ecotoxicological study are anticipated to occur in the Adsorption /desorption test. For this reasoning the adsorption/desorption measurement according to the OECD Test Guideline No. 106 and EU method C.18 is expected to be not feasible. - Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
Description of key information
No Koc value is available as the test is technically unfeasible.
Key value for chemical safety assessment
Additional information
Because of the physical and chemical properties of MOVE3 the experimental determination of Koc is not technically feasible.
However, based on the information available MOVE 3 is not expected to have a significant potential for adsorption. In fact during the attempt to develop an analytical method for the quantification of MOVE3 in octanol (CRL 2017), rapid volatilization of the substance from octanol was observed. Tendency to rapid volatilization from octanol was also observed in the Kow study performed in 2020 (PROCESSIUM 2020) where specific measures were put in place for avoiding volatilization.
As the partition coefficient octanol-water provides indications on the tendency of a substance to adsorb to organic matter it can be concluded that in a system organic matter-air MOVE3 would not have significant tendency to distribute to organic phase and it would rather distribute to air.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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