Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 293-917-2 | CAS number: 91648-55-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment Adopted according to OECD SIDS or other official EU regulation procedures (public available peer reviewed source).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
- Principles of method if other than guideline:
- Method: other: P&G standard procedure #1; comparable or similar to OECD Guideline 401.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sulfuric acid, mono-C12-18-alkyl esters, sodium salts
- EC Number:
- 273-257-1
- EC Name:
- Sulfuric acid, mono-C12-18-alkyl esters, sodium salts
- Cas Number:
- 68955-19-1
- IUPAC Name:
- sodium pentadecyl sulfate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Cox CD
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 2500, 3500, 4900 and 6850 mg/kg bw
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 010 mg/kg bw
- Based on:
- act. ingr.
Any other information on results incl. tables
LD50 (confidence limits): 3390 - 4740 mg/kg
MORTALITY
-Time of death: all deaths occurred within 24 hrs to 7 days after dosing
-Number of deaths at each dose:
2500 mg/kg: 0/10
3500 mg/kg: 5/10
4900 mg/kg: 6/10
6850 mg/kg: 10/10
CLINICAL SIGNS
>= 2500 mg/kg: slight to moderate decreased motor activity and respiratory
rate, blanching, abdominal griping and diarrhoea
>= 3500 mg/kg: slight degrees of haemorrhagic rhinitis; persistent
symptoms and delayed deaths were noted up to seven days post-treatment
6850 mg/kg: slight loss of corneal reflex and pupilary responses
NECROPSY FINDINGS
necropsy of survivors: no abnormalities
POTENTIAL TARGET ORGANS
-none
SEX-SPECIFIC DIFFERENCES
-none
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
