2,4-dichlorophenol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1978

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: The SIDS document does not provide a good description of the methodology used. However the adverse result means that this cannot be discounted.

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

1978

Materials and methods

Test guideline

Qualifier:

no guideline available

Guideline:

other: Method not specified

Principles of method if other than guideline:

Rabbits are exposed to the substance at concentration of 80% in water, during 1 minute, 5 minutes, 15 minutes and 20 hours. The observation was done after 24 hours and 8 days

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,4-dichlorophenol

EC Number:

204-429-6

EC Name:

2,4-dichlorophenol

Cas Number:

120-83-2

Molecular formula:

C6H4Cl2O

IUPAC Name:

2,4-dichlorophenol

Details on test material:

2,4-Dichlorophenol, no additional detail on the substance purity is given

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

No additional details on the test animals or the environmental conditions are reported.

Test system

Type of coverage:

not specified

Preparation of test site:

not specified

Vehicle:

water

Controls:

not specified

Amount / concentration applied:

80% solution of the test substance in water was administered.

Duration of treatment / exposure:

Rabbits are exposed to the substance at concentration of 80% in water, during 1 minute, 5 minutes, 15 minutes and 20 hours.

Observation period:

The observation was carried out after 24 hours and 8 days

Number of animals:

Not known

Details on study design:

No additional data presented

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Remarks on result:

other: Substance is highly corrosive

Irritant / corrosive response data:

From 15 minutes to 20 hours time exposure, there was persistent strong necrosis, oedema and reddening. The necrosis was not reversible.

Other effects:

No additoinal effects reported

Any other information on results incl. tables

In this study, rabbits were exposed to the substance at a concentration of 80% in water, for 1 minute, 5 minutes, 15 minutes and 20 hours.Observations were made after 24 hours and 8 days. From 15 minutes to 20 hours time exposure, there was persistent strong necrosis, oedema and reddening and there wasn't reversibility for the necrosis. This study (not GLP) has served to classify the substance in the EU as corrosive (R34). No details on the purity of the substance, the number and the strain of animals tested and the method used is given.

Applicant's summary and conclusion

Interpretation of results:

highly corrosive

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The substance is regarded as highly corrosive. This result is cited in BUA (German advisory committee on existing chemicals) and has been used to classify the substance as corrosive by INRS (National Institute on Environmental and Industrial Risk)

Executive summary:

The test substance was the subject of a skin irritation study in rabbits. No information on the guideline followed or method employed is reported. The study was not conducted to GLP. The substance was administered as an 80% solution in water. Rabbits were exposed to the solution for 1 minute, 5 minutes, 15 minutes and 20 hours. Observation was carried out after 24 hours and 8 days. Between 15 minutes and 20 hours exposure there was persistent strong necrosis, oedema and erythema. The necrosis was not reversible.

This result is cited in BUA (German advisory committee on existing chemicals) and has been used to classify the substance as corrosive by INRS (National Institute on Environmental and Industrial Risk).