Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-168-5
CAS number: 21041-95-2
Histopathology incidence and severity
Histio-cytic cell granu-lomas
A repeated dose inhalation exposure study
was conducted in female Wistar rats to determine the effects of the test
material on lungs.
Female Wistar rats were exposed to
concentrations of 25, 50 and 100 μg Cd/m³ (as cadmium oxide), continuous
for 90 d in the 25 and 50 μg Cd/m3 groups, and for 63 d in the last
group (MMAD: 0.19 μm, standard deviation: 1.5).
No clinical signs were reported. A marked
increase of lung weight was found together with no signs of oedema.
Histologically, there were cell proliferations of the bronchi,
bronchioli and alveoli in all exposed animals, indicating hyperplasia of
the lungs. Additionally, histiocytic cell granulomas occurred and
emphysematic areas were detected. There was an impairment of gas
exchange in the high exposed group. Pulmonary changes did preceed the
renal damage (assessed by protein and alkaline phosphatase excretion,
histological examination of the kidneys).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again