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EC number: 244-168-5
CAS number: 21041-95-2
A study was conducted to study the effect of
test material inhalation on the infectivity of an orthomyxovirus
influenza strain in Swiss albino mice.
A total of 132 animals were employed in this
study. Animals were exposed to the test material microparticles at 9.02
mg Cd/m3 and observed for 17 d. 48 h after test material
exposure, the animals were infected with an orthomyxovirus influenza
Mice intoxicated by test material but not
infected had reversible general (body weight) and local (local/body
weight ratio) biometric disturbances. In intoxicated and infected
animals, infectious death rate was significantly lower than in Al2O3
exposed animals or virus controls. Virus titration in lung confirmed the
infectious death rate; at the Day 10 after infection, the virus titer in
lung of test material exposed mice was lower than in virus controls.
Hence, under the conditions of the test, the
test material inhaled animals were found to be protected against the
infection by the influenza virus.
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