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EC number: 251-717-2 | CAS number: 33885-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 October 2002 - 7 November 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- In the selection of doses, which are suggested to be one or more of the four fixed levels: 5, 50, 300 and 2000 mg/kg bw. Instead the doses of 200 and 2000 mg/kg bw were used.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-propionaldehyde
- EC Number:
- 251-717-2
- EC Name:
- 6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-propionaldehyde
- Cas Number:
- 33885-51-7
- Molecular formula:
- C12H18O
- IUPAC Name:
- 3-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)propanal
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar Crl: (WI) BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, Sutzfeld, Germany
- Age at study initiation: young adults, 8-9 weeks
- Weight at study initiation: body weight variation did not exceed 20% of the sex mean
- Fasting period before study: ~20 h
- Housing: 3 animals per sex per cage in labelled Macrolon cages with purified sawdust as bedding material
- Diet: standard pelled laboratory animal diet, ad libitum
- Water: ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ±3
- Humidity (%): 30-70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 2.10 mL/kg (for 2000 mg/kg bw dose)
- Doses:
- 200 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 (highest dose only females)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: The animals were observed 30 minutes, 1, 2 and 4 hours after application and thereafter daily
- Necropsy of survivors performed: yes, at the end of the observation period the animals were killed by CO2 asphyxia, necropsied and subjected to examination for gross pathological changes.
- Body weights: Individual body weights were recorded immediately before treatment (day 1) and then on the 8th and 15th day of the observation period.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 2/3 animals died at 2000 mg/kg bw, 1/6 animals died at 200 mg/kg bw.
- Mortality:
- - 2000 mg/kg bw: 2/3 animals died.
- 200 mg/kg bw: 1/6 animals (0/3 females, 1/3 males) died. - Clinical signs:
- - 2000 mg/kg bw: Lethargy, flat and hunched posture, tremors, rales, uncoordinated movements, slow breathing, piloerection was observed.
- 200 mg/kg bw: Females: lethargy, hunched posture, quick breathing, piloerection, salivation. Males: lethargy, flat and hunched posture, uncoordinated movements, piloerection, shallow respiration, ptosis, hypersensitivity to touch. - Body weight:
- No treatment related changes were recorded in the body weights of the animals during the study period.
- Gross pathology:
- No abnormalities observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: Harmful
- Remarks:
- in accordance with EU CLP (EC no 1272/2008 and its amendments)
- Conclusions:
- The substance has an LD50 of between 200 and 2000 mg/kg bw in an OECD TG 423 test.
- Executive summary:
The acute oral toxicity in female and male rats has been studied in accordance with OECD TG 423 and GLP principles. In this study, 9 Wistar rats (3 males and 6 females in total) were administered the substance at dose levels of 200 and 2000 mg/kg bw by oral gavage. Mortality was observed in 2 out of 3 female animals at the highest dose. One male out of six died when dosed with 200 mg/kw bw. Clinical signs observed were lethargy, flat and hunched posture, tremors, rales, uncoordinated movements, slow breathing and piloerection detected. These effects were more prominent in the highest dose group. No body weight or macroscopical abnormalities were detected. The acute oral LD50 for the substance in male and female rats was determined to be between 200 and 2000 mg/kg bw and to derive a point value the geometric mean was selected and resulted in an LD50 of 632 mg/kg bw.
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