1,10-decanediyl bismethacrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March - April 1986

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

1981

Deviations:

no

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,10-decanediyl bismethacrylate

EC Number:

229-745-1

EC Name:

1,10-decanediyl bismethacrylate

Cas Number:

6701-13-9

Molecular formula:

C18H30O4

IUPAC Name:

decane-1,10-diyl bis(2-methylacrylate)

Test material form:

liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, Fuellinsdorf, Switzerland
- Females (if applicable) nulliparous and non-pregnant: [yes/no]
- Age at study initiation: 9 weeks
- Weight at study initiation: males = 224-250g ; females = 160 -197 g
- Fasting period before study: yes
- Housing: groups of 5
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least one week

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/-3
- Humidity (%): 40-70
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Details on oral exposure:

The preparation was made immediately prior to dosing.
The animals received the test article on a mg/kg bw base by oral gavage after being fasted for 12 to 18 hours (access to water was not interrupted). Food was agin presented approximately one hour after dosing.
Volume d'application = 20 ml

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 15 days
- Frequency of observations : four times during test day 1, and daily during days 2-15
- Frequency of weighing: on day 1 (pre-administration), 8 and 15
- Necropsy of survivors performed: yes

Statistics:

no

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD0

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

No mortality

Clinical signs:

No signes of symptoms observed

Body weight:

No change

Gross pathology:

No macroscopic organ changes were observed

Other findings:

no

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The acute oral toxicity of Decanemethylendimethacrylate in rats of both sexes, observed over a period of 15 days, was estimated to be greater than 5000 mg/kg.

Executive summary:

The test article decanemethylendimethacrylate was administered to rats of both sexes by oral gavage, at a dose of 5000 mg/kg.

No death, no clinical signs, no change of body weight and no macroscopic changes were observed.

Indeed, the acute oral toxicity of Decanemethylendimethacrylate in rats of both sexes, observed over a period of 15 days, was estimated to be greater than 5000 mg/kg.