Registration Dossier

Classification & Labelling & PBT assessment

GHS

General Information

Not classified
Implementation:
EU
Remarks:

Human health and Environmental Hazard classification of diarsenic triselenide

 

Diarsenic triselenide is an amorphous glass.

 

According to the scientific literature and as recognised in the ECHA Guidance for Annex V (ECHA, 2012), glass is the state of a substance rather than a substance as such. The physico-chemical and hazard properties of the constituents in the glass are not the same anymore compared to the physico-chemical and hazard properties of the individual consituents separately: arsenic metal and selenium metal.

 

Despite diarsenic triselenide should not be seen as an alloy, metal alloys are another example of where a combination of metals (in an alloy or in a glass) has clearly distinctive properties compared to a classical mixture of its metal components. According to the ECHA Guidance on application of the CLP criteria (ECHA, 2015), metal alloys are defined by the CLP as ‘special preparations’ because their (eco)toxicity profile differs from that of their constituents.

 

For these reasons, the CLP harmonized classifications on “As compounds” and “Se compounds” are not applicable to GASIR 5. After all, the “As compounds” and “Se compounds” hazard classification is based on the hazard of the dissociated arsenic and selenium constituents and assume the properties of arsenic and selenium are the same in their respective compounds.

 

Consequently, the CLP harmonized classficiation should be based on available (eco-)toxicity data on Gasir 5. Aseries of toxicity tests (in accordance with REACH annex VII) have been conducted.In table 4, the EU classification based on the outcome of various toxicity tests (based on REACH annex VII requirements) is presented.

 

Table 1:EU Classification status of diarsenic triselenide based on the toxicity tests.

 

 

Standard test

Outcome

Classification conclusion

HUMAN TOXICITY

Acute oral toxicity

OECD 420

LD50 > 2000 mg/kg

No Classification

Skin irritation

OECD 439

Negative

No Classification

Eye irritation – in vitro

Eye irritation – in vivo

OECD 438

OECD 405

Negative

Negative

Not a severe irritant

No classification

Skin sensitisation

OECD 429

Negative

No Classification

Mutagenicity

OECD 471

Negative

No Classification

ECOTOXICITYY

Environmental toxicity – Transformation/dissolution test

OECD 29

Acute and chronic metal dissolution is lower than the respective environmental reference values[i]

No Classification

 

 

In conclusion, the result of the toxicity tests illustrate the absence of hazards for the annex VII REACH endpoints, demonstrating strong distinctive differences in toxicity and classification from classical mixtures of crystalline selenium and arsenic compounds.

 


References

 

ECHA. 2012. Guidance for Annex V Exemptions from the obligation to register. ECHA-10-G-02-EN, European Chemicals Agency, Helsinki, Finland.

 

ECHA. 2015. Guidance on the application of the CLP criteria. ECHA-15-G-05-EN. ISBN: 978-92-9247-413-3. Version 4.1. June 2015. European Chemicals Agency, Helsinki, Finland.


[i]The Transformation dissolution (T/D) test (OECD 29) is a test that determines the rate and extent to which metals and sparingly-soluble metal compounds can produce soluble available metal ions in aqueous media (I.e. freely available metal ion = toxic entity).The measured dissolved concentration of the individual metal of the complex metal compound/mixtures are compared to their respective Environmental Reference Value (ERV); exceeding one of the individual acute/chronic ERVs, triggers a respective acute/chronic classification of the complex metal compound under consideration.

 

Related composition

Related composition:
Composition 4
Composition 5

Classificationopen allclose all

Explosives
Reason for no classification:
conclusive but not sufficient for classification
Flammable gases and chemically unstable gases
Reason for no classification:
conclusive but not sufficient for classification
Aerosols
Reason for no classification:
conclusive but not sufficient for classification
Oxidising gases
Reason for no classification:
conclusive but not sufficient for classification
Gases under pressure
Reason for no classification:
conclusive but not sufficient for classification
Flammable liquids
Reason for no classification:
conclusive but not sufficient for classification
Flammable solids
Reason for no classification:
conclusive but not sufficient for classification
Self-reactive substances and mixtures
Reason for no classification:
conclusive but not sufficient for classification
Pyrophoric liquids
Reason for no classification:
conclusive but not sufficient for classification
Pyrophoric solids
Reason for no classification:
conclusive but not sufficient for classification
Self-heating substances and mixtures
Reason for no classification:
conclusive but not sufficient for classification
Substances and mixtures which in contact with water emit flammable gases
Reason for no classification:
conclusive but not sufficient for classification
Oxidising liquids
Reason for no classification:
conclusive but not sufficient for classification
Oxidising solids
Reason for no classification:
conclusive but not sufficient for classification
Organic peroxides
Reason for no classification:
conclusive but not sufficient for classification
Corrosive to metals
Reason for no classification:
conclusive but not sufficient for classification
Desensitized explosives
Reason for no classification:
conclusive but not sufficient for classification
Acute toxicity - oral
Reason for no classification:
conclusive but not sufficient for classification
Acute toxicity - dermal
Reason for no classification:
conclusive but not sufficient for classification
Acute toxicity - inhalation
Reason for no classification:
conclusive but not sufficient for classification
Skin corrosion / irritation
Reason for no classification:
conclusive but not sufficient for classification
Serious eye damage / eye irritation
Reason for no classification:
conclusive but not sufficient for classification
Respiratory sensitisation
Reason for no classification:
conclusive but not sufficient for classification
Skin sensitisation
Reason for no classification:
conclusive but not sufficient for classification
Aspiration hazard
Reason for no classification:
conclusive but not sufficient for classification
Reproductive toxicity
Reason for no classification:
data lacking
Effects on or via lactation
Reason for no classification:
data lacking
Germ cell mutagenicity
Reason for no classification:
data lacking
Carcinogenicity
Reason for no classification:
data lacking
1. Specific target organ toxicity - single
Reason for no classification:
data lacking
1. Specific target organ toxicity - repeated
Reason for no classification:
data lacking
Hazardous to the aquatic environment (acute / short-term)
Reason for no classification:
conclusive but not sufficient for classification
Hazardous to the aquatic environment (long-term)
Reason for no classification:
conclusive but not sufficient for classification
Hazardous to the ozone layer
Reason for no classification:
conclusive but not sufficient for classification

Labelling

Signal word:
No signal word

Notes