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Diss Factsheets
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EC number: 425-320-1 | CAS number: 690-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute Inhalation Toxicity: LC50=>2833400 mg/m³ (OECD 403; GLP)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study.
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline No 403, Acute Inhalation Toxicity, May 1981.
- GLP compliance:
- yes
- Limit test:
- no
- Species:
- other: Rat, Crl:CD BR
- Vehicle:
- other: compressed air
- Details on inhalation exposure:
- Whole body exposure
- Duration of exposure:
- 4 h
- Dose descriptor:
- LC50
- Effect level:
- > 457 000 ppm
- Exp. duration:
- 4 h
- Clinical signs:
- other: Signs of toxicity related to dose levels: During the exposure, hyperactivity and then prostration were noted for all animals. At the one-hour post-exposure observation, there were no toxicological significant signs noted. All animals appeared normal on da
- Gross pathology:
- Effects on organs:
Four animals (1M,3F) had dark red lungs noted at necropsy.
Two females had cysts on the kidneys and one female had an enlarged pituitary gland. There were no other findings at the schedulded necropsy. - Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 2 833 400 mg/m³
- Quality of whole database:
- Information from migrated NONS file, as per inquiry number 06-2120010181-80-0000, permission to refer granted by ECHA.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute Toxicty: Inhalation
One acute inhalation toxicity study in the rat was available. In the key study (OECD 403, GLP), there were no mortalities. Two animals exhibited slight body weight loss from day 0 to day 3 (less the 4% of day 0 weight). Four animals (1M, 3F) had dark red lungs noted at necropsy. Two females had cysts on the kidneys and one female had an enlarged pituitary gland.
As no deaths were observed, the LC50 value for the acute inhalation toxicity endpoint is > 457000 ppm (2833400 mg/m3).
Justification for selection of acute toxicity – oral endpoint
In accordance with Column 2 of Annex VII Section 8.5.1, the study is not required for gases if a study on acute toxicity by the inhalation route is available.
Justification for selection of acute toxicity – inhalation endpoint
Only 1 key study available.
Justification for selection of acute toxicity – dermal endpoint
In accordance with Column 2 of Annex VIII Section 8.5, as there is only 1 route of exposure (inhalation), information for only that route need be provided.
Justification for classification or non-classification
Based on the available information in the dossier, the substance 1,1,1,3,3,3-Hexafluoropropane (CAS No. 690-39-1) does not need to be classified for acute toxicity or specific target organ toxicity - single exposure when the criteria outlined in Annex I of 1272/2008/EC are applied.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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