Registration Dossier

Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2015

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified
Type of study:
mouse local lymphnode assay (LLNA)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder

Results and discussion

In vivo (LLNA)

Results
Parameter:
EC3
Value:
6.35
Remarks on result:
other: Batabase: SKin sensitisation

Any other information on results incl. tables

Software Method Endpoint Alert Predicted value
ChemProp Enoch et al Skin Sensitisation Structural Alerts were found. Active
Toxtree Skin sensitisation reactivity domains Skin Sensitisation Structural Alert was found. Acyl Transfer

Applicant's summary and conclusion

Interpretation of results:
Category 1B (indication of skin sensitising potential) based on GHS criteria
Conclusions:
According to (Q)SAR modell: QSAR Toolbox, the predicted values indicated that cis-HPD-tartarate is sensitiser. The result meets the requirement of Hazard Category 1B.