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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study was not performed according to GLP; however, test parameters were well documented, thus data are scientifically acceptable.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The test has been conducted prior to the current OECD guideline.
GLP compliance:
no
Type of study:
open epicutaneous test

Test material

Constituent 1
Chemical structure
Reference substance name:
(E)-4-decenal
EC Number:
265-741-6
EC Name:
(E)-4-decenal
Cas Number:
65405-70-1
Molecular formula:
C10H18O
IUPAC Name:
(E)-4-decenal
Test material form:
other: liquid
Details on test material:
Material: GIV 3-1094

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
epicutaneous, open
Vehicle:
other: in a suitable vehicule (ethanol, acetone, H2O, vaseline or PEG
Concentration / amount:
3, 10, 30 and 100% (undiluted)
Challengeopen allclose all
Route:
epicutaneous, open
Vehicle:
other: in a suitable vehicule (ethanol, acetone, H2O, vaseline or PEG
Concentration / amount:
3, 10, 30 and 100% (undiluted)
No. of animals per dose:
one to six experimental groups and one control group of 6 to 8 guinea pigs are used

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
other: Day 21 and 35
Hours after challenge:
24
Group:
other: treated groups and control group
Dose level:
3%, 10%, 30% and 100%
No. with + reactions:
0
Total no. in group:
4
Remarks on result:
other: Reading: other: Day 21 and 35. . Hours after challenge: 24.0. Group: other: treated groups and control group. Dose level: 3%, 10%, 30% and 100%. No with. + reactions: 0.0. Total no. in groups: 4.0.
Reading:
other: Day 21 and 35
Hours after challenge:
48
Group:
other: treated groups and control group
Dose level:
3%, 10%, 30% and 100%
No. with + reactions:
0
Total no. in group:
4
Remarks on result:
other: Reading: other: Day 21 and 35. . Hours after challenge: 48.0. Group: other: treated groups and control group. Dose level: 3%, 10%, 30% and 100%. No with. + reactions: 0.0. Total no. in groups: 4.0.
Reading:
other: Day 21 and 35
Hours after challenge:
72
Group:
other: treated groups and control group
Dose level:
3%, 10%, 30% and 100%
No. with + reactions:
0
Total no. in group:
4
Remarks on result:
other: Reading: other: Day 21 and 35. . Hours after challenge: 72.0. Group: other: treated groups and control group. Dose level: 3%, 10%, 30% and 100%. No with. + reactions: 0.0. Total no. in groups: 4.0.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: other: EU GHS
Conclusions:
Epicutaneous challenge tests are negative. GIV 3-1094 does not sensitize the Guinea pigs in OET.