Registration Dossier
Registration Dossier
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EC number: 200-625-0 | CAS number: 66-27-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute inhalation toxicity of Methane sulfonic Acid (CAS no: 75-75-2) in rat.
- Author:
- Jay A. Brown
- Year:
- 2 017
- Bibliographic source:
- Haz-Map®: Information on Hazardous Chemicals and Occupational Diseases, U.S. National Library of Medicine, October 2017.
- Reference Type:
- review article or handbook
- Title:
- Acute inhalation toxicity of Methane sulfonic Acid (CAS no: 75-75-2) in rat
- Author:
- John Wiley & Sons
- Year:
- 2 012
- Bibliographic source:
- Patty's Industrial Hygiene and Toxicology, 2012.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity of Methane sulfonic Acid (CAS no: 75-75-2) in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Methanesulphonic acid
- EC Number:
- 200-898-6
- EC Name:
- Methanesulphonic acid
- Cas Number:
- 75-75-2
- Molecular formula:
- CH4O3S
- IUPAC Name:
- Methanesulphonic acid
- Details on test material:
- - Name: Methane sulfonic Acid
- InChI: 1S/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4)
- Smiles: S(=O)(=O)(C)O
- Molecular formula:CH4O3S
- Molecular weight:96.1056 g/mole
- Substance type:Organic
- Physical state:Light yellow liquid
Constituent 1
- Specific details on test material used for the study:
- - Name: Methane sulfonic Acid
- InChI: 1S/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4)
- Smiles: S(=O)(=O)(C)O
- Molecular formula:CH4O3S
- Molecular weight:96.1056 g/mole
- Substance type:Organic
- Physical state:Light yellow liquid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 6 h
- Remarks on duration:
- not specified
- Concentrations:
- 330 ppm (330000 mg/m3)
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 330 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at 330 ppm.
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute inhalation toxicity dose (LC50) was considered to be >330 ppm (330000 mg/m3), when rats were exposed to Methane sulfonic Acid (CAS no: 75-75-2) by inhalation route.
- Executive summary:
The acute inhalation toxicity study was conducted by using Methane sulfonic Acid (CAS no: 75-75-2) in rats at the concentration of330 ppm (330000 mg/m3). No mortality was observed at 330000 mg/m3. Therefore, LC50 was considered to be >330 ppm (330000 mg/m3), when rats were treated withMethane sulfonic Acid by inhalation.
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