Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
experimental phase from 2014-10-17 to 2014-10-22
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. The test substance is adequately characterised. Therefore full validation applies.
Qualifier:
according to
Guideline:
OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
Version / remarks:
2006
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. certificate)
Remarks:
inspected on June 3 to 5, 2013 / signed on November 5, 2013
Type of method:
slow-stirring method
Partition coefficient type:
octanol-water
Analytical method:
gas chromatography
Key result
Type:
log Pow
Partition coefficient:
3.66
Temp.:
25 °C
pH:
5.82

Method Validation:

The analytical method on test substance was validated with satisfactory results regarding linearity, limit of quantification, accuracy, precision and specificity.

Table 4.7/1: Partition coefficient - results

Replicate

Test

Measured concentration

POW

Log POW

number

Duration [h]

in n-octanol
[mg/L]

in aq. phase
[mg/L]

 

Single

Mean

SD ±

CV

1

69.98

19235

4.31

4459

3.65

3.65

0.03

0.79

74.99

18993

4.59

4140

3.62

94.35

22414

4.60

4869

3.69

99.65

20603

4.57

4507

3.65

2

69.98

21166

4.46

4747

3.68

3.66

0.04

1.05

74.99

18631

4.57

4076

3.61

94.35

22092

4.41

5009

3.70

99.65

19999

4.47

4469

3.65

3

69.98

21609

4.43

4882

3.69

3.67

0.03

0.82

74.99

21649

4.60

4703

3.67

94.35

18913

4.47

4227

3.63

99.65

21730

4.43

1909

3.69

 

 

 

 

log POW,Av

3.660

 

 

 

 

 

 

slog POW,Av

0.003

 

 

 

Regression analysis demonstrated that the slope of the regression line of the log Pow of the four successive samples was not significantly different from zero. Therefore equilibrium was considered to be achieved. The mass balance ranges between 93 and 111%.

Conclusions:
The substance has low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4).
Executive summary:

The partition coefficient of the test substance was measured under GLP according to the OECD 123 guideline, slow stirring method.

The partition coefficient (n-octanol/water) (log Pow) of test substance was determined at test temperature of 25 ± 1 °C and at a pH value of 5.8 from three independent replicates (test vessels) with four sub-replicates (samples).

Quantification was performed using validated GC-MS analytical method.

 

Partition coefficient (log Pow) of test substance was determined to be 3.660 ± 0.003.

Description of key information

The substance has low potential for bioaccumulation, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4).

Key value for chemical safety assessment

Log Kow (Log Pow):
3.66
at the temperature of:
25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD method and under GLP, is available. Therefore, it is considered as a key study, and the result is retained as key value for purpose of CSA.

The data is relevant for classification in aquatic chronic toxicity hazard class, according to CLP criteria.