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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From July 25 to 31, 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. The test substance is adequately characterised. Therefore full validation applies.
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Regulation (EC) N°440/2008
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. certificate)
Remarks:
UK GLP compliance programme (inspected on March 12 to 14, 2014 / signed on May 12, 2014)
Type of method:
gas saturation method
Key result
Temp.:
25 °C
Vapour pressure:
3.2 Pa

Results of the vapor pressure determinations

Saturator

Column.

Temperature (°C)

Volume* V (mL)

Mass of test item in Trap 1 (µg)

Mass of test item in Trap 2 (µg)

Total mass of test item (µg)

Vapor pressure (Pa)

Average Vapor pressure [Pa] (Std Dev)

A          

25

8383

2109.750

6.543

2116.293

3.25

3.26 (1.79 * 10-2)

B

11177

2183.850

3.331

2817.181

3.25

C

13972

3554.050

3.578

3557.628

3.28

A

35         

6092

3524.100

2.717

3526.817

7.71

7.77 (0.124)

B

8123

4677.505

3.123

4680.173

7.68

C

10153

6019.500

7.186

6026.686

7.91

A

45

4263

5554.500

4.255

5558.755

17.9

18.0 (0.269)

B

5684

7338.500

3.702

7342.202

17.8

C

7105

9447.000

2.978

9449.978

18.3

                                                                                                                                             

*Corrected volume at test temperature as calculated under “Volume correction” 

                                     

Validation

The linearity of the detector response with respect to concentration was assessed over the concentration range of 1.07 to 1.07 X 103 mg/L (n = 7). The results were satisfactory with a correlation coefficient of 1.000 being obtained.

The concentrations in the sample solutions from traps 1 ranged between 42.2 and 189 mg/L, and therefore, were within the calibration range. For traps 2 (0.05 —0.14 mg/L), inaccuracy in the determination is considered negligible as this collected fraction represents less than 0.5% of the total amount.

Conclusions:
Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).
Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, gas saturation method.

Determinations were conducted at 25, 35 and 45 °C, with three flow rates per temperature. Mass of evaporated test item was quantified by GC. Vapor pressure at 25 °C was interpolated from the regression.

The vapor pressure of the test item has been determined to be 3.2 Pa at 25 °C.

Description of key information

Low volatility.

Key value for chemical safety assessment

Vapour pressure:
3.2 Pa
at the temperature of:
25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study, and the result is retained as key data for purpose of CSA.