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EC number: 203-560-6 | CAS number: 108-20-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
Description of key information
A NOAEC of 7060 ppm (29500 mg/m3), the highest concentration tested, was derived from the results of a 13-week diisopropyl ether inhalation neurotoxicity study in Sprague-Dawley rats (similar to OECD Test Guideline 424).
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via inhalation route
Link to relevant study records
- Endpoint:
- neurotoxicity: sub-chronic inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with detailed documentation
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 424 (Neurotoxicity Study in Rodents)
- Deviations:
- yes
- Remarks:
- source of test material not reported, and ophthalmology was not performed
- GLP compliance:
- no
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- 5 days/week for 6 hours/day
- Remarks:
- Doses / Concentrations:
450, 3250, 7060 ppm
Basis:
other: measured - No. of animals per sex per dose:
- 10 animals/sex/dose
- Control animals:
- yes
- Dose descriptor:
- NOAEL
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
- Executive summary:
A NOAEC value was not reported by the study authors. Review of the study data suggests that the NOAEC can be considered to be 7060 ppm (29500 mg/m3), the highest concentration tested. This consideration is based on the observation that the effects that were noted in the study were small in magnitude, did not occur in both sexes, were not concentration-dependent, and were transient in nature (i.e., did not occur at all time points investigated). This is consistent with the authors’ statement that “…some nonbiologically significant changes were observed in both the FOB and motor activity.”
Reference
Body weights and clinical observations were not affected by exposure to DIPE. The pinna reflex was significantly reduced in the low dose males when compared to the controls during week 2. Unperturbed activity level was significantly decreased in low- and high-dose females when compared to the controls in week 4. Rectal temperature in the low-dose males was significantly increased in week 4 when compared to the controls. Although motor activity of control animals tended to decrease as the animals aged, there was a significant decrease in high-dose females when compared to the control animals in week 4. Motor activity in the high-dose group (males and females) remained consistant throughout the study but tended to be lower than the controls until week 13. In contrast, motor activity was significantly increased in low dose females in week 8. No effects were observed in the central or peripheral nervous system of the high-dose group, however, in one female in the low-dose group, a large cavity was noted in the cerebrum. In the same female, microscopic examination revealed focal hypoplasia of the cortex and the white matter tracks serving this area of the cortex. The dorsolateral region of the thalamus adjacent to the dilated ventricle was also hypoplastic. There was no evidence of neuronal degeneration, inflammation, or gliosis within the brian sections of this rat.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 29 500 mg/m³
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Rodriguez and Dalbey (1997) conducted a 13-week diisopropyl ether inhalation neurotoxicity study in Sprague-Dawley rats. The study design was similar to OECD Test Guideline 424 but was not conducted per GLP. Ten rats/sex/group were exposed to diisopropyl ether at concentrations of 0, 450, 3250, or 7060 ppm (equivalent to 0, 1900, 13600, or 29500 mg/m3, respectively) for 13 weeks (6 hours/day for 5 days/week). Rats were observed daily for signs of toxicity and body weights were recorded weekly. The animals were evaluated in a functional observational battery (FOB) followed by a determination of motor activity prior to initiation of exposures, in an FOB following 2, 4, 8, and 13 weeks of exposure, and for motor activity following 4, 8, and 13 weeks of exposures. Following the final determination of motor activity, the animals were anesthetized and the brain, spinal cord, and peripheral nerves were removed for microscopic examination.
Body weights and clinical observations were not affected by exposure to diisopropyl ether. The pinna reflex was significantly reduced in the low dose males when compared to the controls during week 2. Unperturbed activity level was significantly decreased in low- and high-dose females when compared to the controls in week 4. Rectal temperature in the low-dose males was significantly increased in week 4 when compared to the controls. Although motor activity of control animals tended to decrease as the animals aged, there was a significant decrease in high-dose females when compared to the control animals in week 4. Motor activity in the high-dose group (males and females) remained consistent throughout the study but tended to be lower than the controls until week 13. In contrast, motor activity was significantly increased in low dose females in week 8. No effects were observed in the central or peripheral nervous system of the high-dose group, however, in one female in the low-dose group, a large cavity was noted in the cerebrum. In the same female, microscopic examination revealed focal hypoplasia of the cortex and the white matter tracks serving this area of the cortex. The dorsolateral region of the thalamus adjacent to the dilated ventricle was also hypoplastic. There was no evidence of neuronal degeneration, inflammation, or gliosis within the brain sections of this rat.
A NOAEC value was not reported by the study authors. Review of the study data suggests that the NOAEC can be considered to be 7060 ppm (29500 mg/m3), the highest concentration tested. This consideration is based on the observation that the effects that were noted in the study were small in magnitude, did not occur in both sexes, were not concentration-dependent, and were transient in nature (i.e., did not occur at all time points investigated). This is consistent with the authors’ statement that “…some nonbiologically significant changes were observed in both the FOB and motor activity.”
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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