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EC number: 265-058-3
CAS number: 64741-57-7
A complex combination of hydrocarbons produced by the vacuum distillation of the residuum from atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C20 through C50 and boiling in the range of approximately 350°C to 600°C (662°F to 1112°F). This stream is likely to contain 5 wt. % or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
Results of mouse skin painting tests and initiation/promotion assays, together with modified Ames tests, and chemical (PAH) analysis indicate that Heavy Fuel Oil Components, particularly those containing cracked material, are carcinogenic.
Positive results in mouse skin painting
studies and an initiation/promotion assay, together with supporting
modified Ames data and
Classification Carcinogenic 1B, H350
is appropriate under the EU
CLP Regulation (EC No. 1272/2008).
Results from mouse skin painting studies
demonstrate that cracked Heavy Fuel Oil Components are clearly
dermal carcinogenicity of catalytic cracked clarified oil (0.1%, 1% or
10% in toluene; CAS# 64741 -62 -4) was tested in a key non-guideline
GLP-compliant lifetime mouse skin painting study (API, 1989a). The test
solutions (50 uL) were applied twice weekly to an area of clipped skin
on the dorsum, and the test included appropriate negative (sham,
vehicle) and positive (0.01%, 0.05% benzo(a)pyrene) controls. Treatment
was for the lifetime of the animals. The
test substance elicited skin irritation that was similar in extent and
incidence to that seen in the vehicle controls, with an increased
incidence of malignant tumours with decreased latency present in the
intermediate and high dose groups. A satisfactory response was obtained
for the positive controls. The
report concluded that catalytic cracked clarified oil was a strong
from three skin painting studies on catalytic cracked clarified oil
(CAS#64741 -62 -4) demonstrate a clear increase in incidence of
malignant tumours (carcinomas) with decreased latency. Concentrations of
5% of the test substance in white oil produced tumors in most of the
A single initiation/promotion assay also
demonstrated that catalytically cracked clarified oil (CAS# 64741 -62
-4) is an initiator (API, 1989b).
Overall it can be concluded that both
Straight-run and Cracked Heavy Fuel Oil Components are carcinogenic.
Justification for selection of carcinogenicity via dermal route endpoint:
One of 4 available studies.
Carcinogenicity: via dermal route (target organ): other: skin
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