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Diss Factsheets
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EC number: 426-110-2 | CAS number: 98377-35-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 407
- GLP compliance:
- yes
- Limit test:
- no
Test animals
- Species:
- other: rat, Wistar Hsd Cpb:WU (SPF)
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: demineralisiertes Wasser mit Cremophor EL 2 % (v/v)
- Details on oral exposure:
- Method of administration:
Schlundsonde - Duration of treatment / exposure:
- Test duration: 28 days
- Frequency of treatment:
- Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Male: 5 animals at 0 mg/kg bw/day
Male: 5 animals at 100 mg/kg bw/day
Male: 5 animals at 300 mg/kg bw/day
Male: 5 animals at 1000 mg/kg bw/day
Female: 5 animals at 0 mg/kg bw/day
Female: 5 animals at 100 mg/kg bw/day
Female: 5 animals at 300 mg/kg bw/day
Female: 5 animals at 1000 mg/kg bw/day
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:
Die Männchen der hohen Dosierung nahmen im Vergleich zur
Kontrolle vermehrt Wasser auf.
"ENGLISH"
The intake of water of the males of the high dose group was
increased compared to the control group.
Laboratory findings:
Die klinisch-chemischen Untersuchungen ergaben erhöhte
Aktivität von ALAT bei den Männchen und (nicht signifikant)
bei den Weibchen der hohen Dosierung. Die Männchen der hohen
Dosierung wiesen einen verminderten pH-Wert des Urins sowie
geringgradig erhöhte Urinvolumen auf.
"ENGLISH"
The clicnical-chemical tests were indicating an increased
activity of ALAT at the males and ( not significant) at the
females in the high dose group. The males of the high dose
group showed decreased pH-value of the urine and a low
increase of the urine volume.
Effects in organs:
Bei beiden Geschlechtern der hohen Dosierung wurden erhöhte
absolute und relative Lebergewichte ermittelt. Ebenso waren
bei den Weibchen der hohen Dosierung die absoluten
Nierengewichte erhöht.
Die histopathologischen Untersuchungen ergaben keine
behandlungsbedingten Effekte an den Organen.
In einer zusätzlichen Untersuchung wurde die Aktivität von
mikrosomaler N-Demethylase und der Gehalt an Cytochrom P450
in den Leberzellen bestimmt. Die Bestimmungen ergaben
verminderte Werte für beide Parameter, diese Reduktionen
wurden als toxikologisch nicht relevant bewertet.
"ENGLISH"
In both sexes of the high dose group there were determined
increased absolute and relative lever weights. Moreover the
kidney weights of the females in the high dose group were
increased.
The histopathological investigation did not indicate
treatment-related effects at the organs.
In an additional investigation the activity of microsomal
N-Demethylase and the content of Cytochrom P450 in the liver
cells were determined. The finding was a decrease for
both parameters, but these reductions were assessed as not
being toxicological relevant.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 300 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
- Dose descriptor:
- NOEL
- Effect level:
- 300 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Classified as: Not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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