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Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From August 15, 2000 to January 23, 2001
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Remarks:
(because of low solubility of test substance HPLC method was used)
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
Pow
Partition coefficient:
3 800 000
Temp.:
22.5 °C
pH:
4.8
Key result
Type:
log Pow
Partition coefficient:
6.6
Temp.:
22.5 °C
pH:
4.8
Details on results:
- log Pow (k'1): 6.61
- log Pow (k'2): 6.60
- The mean value of the two measurements is log Pow = 6.6
- The difference of each value to the mean value is smaller than 0.1.
- Pow value: 3800000

None

Conclusions:
Under the test conditions, log Pow of test substance was determined to be 6.6
Executive summary:

A study was performed to determine the partition coefficient of test substance according to OECD Guideline 107 and EU Method A.8. in compliance with GLP.

HPLC method was chosen because of the low solubility of the test substance in water. The mean value of the two measurements was log Pow = 6.6.The difference of each value to the mean value is smaller than 0.1.

 

Under the test conditions, log Pow and Pow of test substance was determined to be 6.6 and 3.8 x 106 respectively

Description of key information

The log Pow of test substance was determined to be 6.6 at 20 °C

Key value for chemical safety assessment

Log Kow (Log Pow):
6.6
at the temperature of:
20 °C

Additional information

A study was performed to determine the partition coefficient of test substance according to OECD Guideline 107 and EU Method A.8. HPLC method was chosen because of the low solubility of the test substance in water. The mean value (log Pow) of the two measurements was 6.6. The difference of each value to the mean value is smaller than 0.1. Log Pow of test substance was determined to be 6.6 (Schleich W, 2001)