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EC number: 202-830-0 | CAS number: 100-21-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 March to 29 June 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Proprietary non-GLP study, conducted according to OECD guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
- Remarks:
- no certificate or statement of compliance included in report
Test material
- Reference substance name:
- Terephthalic acid
- EC Number:
- 202-830-0
- EC Name:
- Terephthalic acid
- Cas Number:
- 100-21-0
- Molecular formula:
- C8H6O4
- IUPAC Name:
- benzene-1,4-dicarboxylic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Terephthalic acid, identification no. 10820-97, described as a white powder and stored at room temperature (approximately 22°C).Purity not stated. However, terephthalic acid is a monomer used in the production of saturated polyesters, and a purified (> 99.9% w/w) feedstock (free of production-process impurities) is essential for this purpose. The batch of terephthalic acid used in this study is considered to have been representative of commercial production and to have been at least 99% pure.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- The animals were New Zealand White rabbits of either sex, weighing approximately 2.0-3.5 kg on arrival. Rabbits were supplied by Johnson Rabbit Ranch, IN. The rabbits were acclimatised for at least 1 week prior to study initiation, during which time they were examined to ensure their health and suitability as test subjects,Each rabbit was housed individually in a suspended stainless steel cage. Poly pads were placed in the pans below the mesh.Approximately 150 g of Purina Lab Rabbit Chow HF #5326 (Ralston Purina Co., St. Louis, MO) was provided daily for each rabbit. Reverse osmosis purified water was available ad libitum.Individuals were identified by metal ear tags and corresponding cage cards. Fluorescent lighting was provided on a 12 hour light/dark cycle.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.5 g undiluted test material was applied (doses were weighed onto aluminium foil).
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours after dressing removal
- Number of animals:
- Three
- Details on study design:
- Prior to study initiation, the backs of all candidate test animals were shaved and checked for abnormalities. Animals found at this stage to have significant skin abnormalities encompassing the entire shaved back were not included in the study.Approximately 24 hours prior to testing, fur from the trunk of the animals was clipped so that no less than 10% (~240 cm²) of the dorsal body surface was available for application.The treated site was covered by a 2.5x2.5 cm adhesive dressing (Coverlet, Beiersdorf). The entire midsection of each rabbit was then wrapped in a lint free cloth towel secured by Elastoplast. Each rabbit had a treated and an untreated test site, to provide a control for comparison.All wrapping materials were removed 4 hours after application. Following unwrapping, the test sites were rinsed with approximately 2 ml of 0.9% saline and towel dried. All rabbits were weighed immediately prior to application of the test material. All animals were observed for morbidity and mortality at least once daily following treatment. All test sites were examined for signs of dermal irritation (oedema, erythema and/or eschar formation) and corrosivity (ulceration and/or necrosis) 30-60 minutes, 24, 48 and 72 hours after removal of the wrappings. The skin reactions were graded according to the Draize method (Draize, 1959).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: No data reported on individual animals
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: No data reported on individual animals
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: No data reported on individual animals
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: No data reported on individual animals
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: No data reported on individual animals
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: No data reported on individual animals
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.2
- Reversibility:
- fully reversible within: 72 hours
- Irritant / corrosive response data:
- No signs of dermal corrosivity were seen in any rabbit during the study. The irritation score ranged from 0.7/8.0 at 30-60 minutes, to 0.0/8.0 at 72 hours following unwrapping.
- Other effects:
- No other effects reported.
Any other information on results incl. tables
The irritation score ranged from 0.7/8.0 at 30-60 minutes, to 0.0/8.0 at 72 hours following unwrapping.
The Primary Dermal Irritation Score for terephthalic acid was 0.2.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The Primary Dermal Irritation Score for Terephthalic Acid was 0.2. No signs of dermal corrosivity were seen in any rabbit during the study.
- Executive summary:
Terephthalic acid was applied for 4 hours to the shaved backs of three rabbits at a dose of 0.5 g. Following unwrapping, the test sites were rinsed with saline. All test sites were examined for signs of irritation and corrosivity according to the Draize method at 30 -60 minutes, 24, 48 and 72 hours following removal of the wrappings. No signs of dermal corrosivity were seen in any rabbit during the study. The irritation score ranged from 0.7/8.0 at 30-60 minutes, to 0.0/8.0 at 72 hours following unwrapping. The Primary Dermal Irritation Score for Terephthalic Acid was 0.2. It can be concluded that terephthalic acid is not irritating to rabbit skin.
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