Registration Dossier
Registration Dossier
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EC number: 449-430-4 | CAS number: 99189-60-3 1,1-CYCLOHEXANE DIACETIC ACID MONOAMIDE (CAM); 1,1-CYCLOHEXANEDIACETIC ACID MONOAMIDE
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,1-cyclohexanediacetic acid monoamide
- EC Number:
- 449-430-4
- EC Name:
- 1,1-cyclohexanediacetic acid monoamide
- Cas Number:
- 99189-60-3
- Molecular formula:
- C10H17NO3
- IUPAC Name:
- 2-[1-(carbamoylmethyl)cyclohexyl]acetic acid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- water
- Controls:
- yes
- Amount / concentration applied:
- single administration of 0.5g of the test item
- Duration of treatment / exposure:
- 3 minutes, 1 hour and 4 hours
- Observation period:
- Immediately and 72 hours after the 3minute and the 1 hour exposure period in the first rabbit and at 1, 24, 48 and 72 hours after the 4-hour exposure period (all rabbits).
- Number of animals:
- 3 males
Results and discussion
Any other information on results incl. tables
No clinical signs, either general or local (at the application sites), were noted in any rabbit.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test article when administered to rabbits by dermal route, was "non irritant" for the skin.
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