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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
other: data sharing dispute
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: data sharing dispute

Data source

Reference
Reference Type:
other: not specified
Title:
Metabolism of L (+) - and D (-) - tartaric acids in different animal species
Author:
Gry J & Larsen JG
Year:
1978
Bibliographic source:
N.A.

Materials and methods

Principles of method if other than guideline:
data sharing dispute

Test material

Constituent 1
Reference substance name:
(+)-tartaric acid
IUPAC Name:
(+)-tartaric acid

Results and discussion

Main ADME resultsopen allclose all
Type:
excretion
Results:
rats and guinea pigs handle the compound in different ways, the pig held an intermediate position in the ability to excrete the tartaric acids.
Type:
excretion
Results:
only in the rat was there a difference in the ability to excrete the two isomers, with a lower recovery of the D(-)-form.
Type:
metabolism
Results:
the in vitro study showed that no difference of decomposition of tartaric acid by the intestinal flora between guinea pig and rat.

Applicant's summary and conclusion