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EC number: 231-150-7
CAS number: 7440-41-7
No studies on repeat exposure to Be metal exists. The publications referenced (three studies reliable) in this section are relevant due to long post-exposure observation period. These were included as they demonstrated the Be is very persistent in lung following inhalation.
Although there are no true repeated dose studies available, the studies
summarized under 7.5.3 are of relevance due to the persistence of Be in
the lung following a single inhalation exposure. Accordingly, there will
be continued exposure following an acute exposure event. Based on
limited evidence, rats seem more susceptible as there were deaths
obsserved in the inhalation study by Haley et al 1990. The effects seen
in the rat lung were also more severe than observed in mice. Common
observations for all studies were long persistence of Be in the lung,
inflammation (granuloma commonly observed) and fibrosis. The latter
effects were both dependent on species and time following exposure.
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