Registration Dossier
Registration Dossier
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EC number: 200-467-2 | CAS number: 60-29-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original publication not available. Data based on IUCLID data summary sheet.
Data source
Reference
- Reference Type:
- publication
- Title:
- Autooxidative injury with loss of cytochrome P-450 following acute exposure of rats of fasting and ether anesthesia.
- Author:
- Liu, P.T., Symons, A.M., Parke, D.V.
- Year:
- 1 991
- Bibliographic source:
- Xenobiotica, 1991, 21, 205-215
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Male rats were fasted for 20 hours and exposed to diethyl ether. Cytochrome P450 levels were monitored.
- GLP compliance:
- no
Test material
- Reference substance name:
- Diethyl ether
- EC Number:
- 200-467-2
- EC Name:
- Diethyl ether
- Cas Number:
- 60-29-7
- Molecular formula:
- C4H10O
- IUPAC Name:
- diethyl ether
- Details on test material:
- No details on test material available.
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- 6 min
Doses / concentrations
- Remarks:
- Doses / Concentrations:
ca. 5000 mg/kg bw
- No. of animals per sex per dose / concentration:
- No data
- Control animals:
- yes
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- Post exposure there was an increase in exhaled alkanes and indication of lipid peroxidation.
Any other information on results incl. tables
Total cytochrome P-450 levels in the liver and kidney were decreased to 25 -30% of the control animals. Levels were normal 2 hours later.
Cytochrome P-450 I levels were decreased to 35 -44% of the control animals. Levels were 80% 2 hours later.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
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