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Diss Factsheets
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EC number: 208-765-4 | CAS number: 541-05-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The study did not meet the criteria of current guidelines for skin irritation testing.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test involved repeated application of 0.5 g undiluted test substance to shaved rabbit skin for 10 days (excluding weekends).
- GLP compliance:
- no
Test material
- Reference substance name:
- Hexamethylcyclotrisiloxane
- EC Number:
- 208-765-4
- EC Name:
- Hexamethylcyclotrisiloxane
- Cas Number:
- 541-05-9
- Molecular formula:
- C6H18O3Si3
- IUPAC Name:
- hexamethyl-1,3,5,2,4,6-trioxatrisilinane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No detail available.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5g
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- The test material was applied daily for 10 days (excluding weekends)
- Observation period:
- Data not available.
- Number of animals:
- 1
- Details on study design:
- TEST SITE
- Area of exposure: abdomen
- Type of wrap if used: The application sites were then covered with a semi-occlusive dressing.
- The abdomen of the rabbit was prepared for testing by shaving the application site. One side of the abdomen was manually abraded while the skin on the opposite was not.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Remarks on result:
- other: The test material produced slight redness only.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: The report did not provide individual animal data including the severity score for skin irritation reactions or the time of its onset and reversibility.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: The report did not provide individual animal data including the severity score for skin irritation reactions or the time of its onset and reversibility.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: The report did not provide individual animal data including the severity score for skin irritation reactions or the time of its onset and reversibility.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: The report did not provide individual animal data including the severity score for skin irritation reactions or the time of its onset and reversibility.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: The report did not provide individual animal data including the severity score for skin irritation reactions or the time of its onset and reversibility.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: The report did not provide individual animal data including the severity score for skin irritation reactions or the time of its onset and reversibility.
- Irritant / corrosive response data:
- The test material produced slight redness only.
- Other effects:
- No data available.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the in vivo skin irritation study, not conducted according to OECD Test Guideline or in compliance with GLP, 10-day repeated application of hexamethylcyclotrisiloxane onto the intact or abraded rabbit skin produced only slight redness, which was not concluded to be sufficient evidence for irritation.
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