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EC number: 221-424-4 | CAS number: 3089-17-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- year of study report: 1991
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary source, original study report not available
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
- Reference Type:
- review article or handbook
- Title:
- High Production Volume (HPV) Challenge Program Test Plan for C.I. Pigment Violet 19 (CAS NO.: 1047-16-1) and C.I. Pigment Red 122 (CAS NO. 980-26-7) and Dihydro Quinacridone (CAS NO. 5862-38-4)
- Author:
- CPMA, Color Pigments Manufacturers Association, Inc. Quinacridone Committee
- Year:
- 2 006
- Bibliographic source:
- http://www.epa.gov/HPV/pubs/summaries/ci19122d/c16303tc.htm
- Report date:
- 2006
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- Toxicokinetic study with oral administration of the radiolabelled test item and examination of the excretion via urine and feces.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 5,12-dihydroquino[2,3-b]acridine-7,14-dione
- EC Number:
- 213-879-2
- EC Name:
- 5,12-dihydroquino[2,3-b]acridine-7,14-dione
- Cas Number:
- 1047-16-1
- Molecular formula:
- C20H12N2O2
- IUPAC Name:
- 5,12-dihydroquino[2,3-b]acridine-7,14-dione
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): C.I. Pigment Violet 19 (CAS NO.: 1047-16-1), QV19
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Duration and frequency of treatment / exposure:
- single exposure with excreta collection up to 72 h post exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
3.22 mg/kg (33.68 uCi/kg) for males, 5.44mg/kg (56.81 uCi/kg) for females
- Control animals:
- other: not required
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Based on the excretion data there is no oral absorption
- Details on excretion:
- Recovery of administered radioactive dose was virtually complete: 91.9 +/- 6.9 % of dose males; 100.5 +/-8.7% of dose females. There were no gender related differences in the route of excretion. More than 90 % of the recovered radioactivity was eliminated in the feces and cage washes, which appeared to contain residual fecal matter. At 72 hours virtually all radioactivity had been eliminated by the rats. The urine from both groups of rats contained very low amounts of radioactivity, 0.0089% of dosed males; 0.0020% of dose females.
Metabolite characterisation studies
- Metabolites identified:
- not measured
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Under the conditons of this study, the systemic absorption of the test item was negligible. - Executive summary:
In this toxicokinetic study, the radiolabelled test item was administered orally per gavage to male and female F-344 rats as a suspension in aqueous 1% carboxymethyl cellulose (3.22 mg/kg (33.68 uCi/kg) for males, 5.44 mg/kg (56.81 uCi/kg) for females). Urine and feces were collected from each rat at 2, 8, 24, 48 and 72 hours after dosing; cage washes and gastrointestinal tract of each rat were removed after euthanasia at 72 hour post-dose. Recovery of administered radioactive dose was virtually complete: 91.9 +/- 6.9 % of dose males; 100.5 +/-8.7% of dose females. There were no gender related differences in the route of excretion. More than 90 % of the recovered radioactivity was eliminated in the feces and cage washes, which appeared to contain residual fecal matter. At 72 hours virtually all radioactivity had been eliminated by the rats. The urine from both groups of rats contained very low amounts of radioactivity, 0.0089% of dosed males; 0.0020% of dose females.
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