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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets generally accepted scientific principles, acceptable for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
- very limited documentation
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Heptane
EC Number:
205-563-8
EC Name:
Heptane
Cas Number:
142-82-5
Molecular formula:
C7H16
IUPAC Name:
heptane
Details on test material:
- Name of test material (as cited in study report): n-Heptane
- Analytical purity: 100% pure commercial product

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
29.29 mg/L nominal
17937.5 ± 5665.92 ppm (mean analytical concentration and SD) = 73.5 mg/L ± 2.32 (re-calculated from ppm value given in study report)
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: not specified, but at least 4 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 29.29 mg/L air (nominal)
Exp. duration:
4 h
Remarks on result:
other: only one concentration tested
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 73.5 mg/L air (analytical)
Exp. duration:
4 h
Remarks on result:
other: only one concentration tested
Sex:
male/female
Dose descriptor:
LC0
Effect level:
>= 29.29 mg/L air (nominal)
Exp. duration:
4 h
Remarks on result:
other: only one concentration tested
Mortality:
No mortality occurred during the course of the study.
Clinical signs:
other: No clinical signs observed throughout the study.
Body weight:
Slight reduction of mean male body weights on day 2 post exposure, but males recovered by day 4.
Female weight changes were minimal.
All animals appeared normal throughout the study.
Gross pathology:
All animals appeared normal at terminal necropsy with the exception of one female with enlarged mandibular lymph nodes on the right side

Any other information on results incl. tables

Normal-Heptane has a low order of toxicity by the inhalation route of exposure.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
Based on the study design Normal-Heptane has a low order of toxicity by the inhalation route of exposure and needs not to be classified.
Executive summary:

Based on the study design Normal-Heptane has a low order of toxicity by the inhalation route of exposure and needs not to be classified.