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Physical & Chemical properties

Dissociation constant

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Description of key information

Dissociation constant: 8.13±0.30 (calculation).

Key value for chemical safety assessment

pKa at 20°C:
8.13

Additional information

According to Guidance on information requirements and chemical safety assessment (Chapter R.7a: Endpoint specific guidance), this endpoint can be waived as there is a lack of relevant functional groups associated with dissociation constant. Attempts to determine the dissociation constant of 2 -ethylhexyl salicylate by the titration method and the spectrophotometric method failed indicating a high pKa indicative of extremely low tendency for dissociation. This could be confirmed by using computational methods (QSAR) predicting a pKa value of 8.13 ±0.30. Hence, there is no need to investigate further.