Registration Dossier
Registration Dossier
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EC number: 204-263-4 | CAS number: 118-60-5
Dissociation constant
Administrative data
Link to relevant study record(s)
Description of key information
Dissociation constant: 8.13±0.30 (calculation).
Key value for chemical safety assessment
- pKa at 20°C:
- 8.13
Additional information
According to Guidance on information requirements and chemical safety assessment (Chapter R.7a: Endpoint specific guidance), this endpoint can be waived as there is a lack of relevant functional groups associated with dissociation constant. Attempts to determine the dissociation constant of 2 -ethylhexyl salicylate by the titration method and the spectrophotometric method failed indicating a high pKa indicative of extremely low tendency for dissociation. This could be confirmed by using computational methods (QSAR) predicting a pKa value of 8.13 ±0.30. Hence, there is no need to investigate further.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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