Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Little information is available about the test conditions and the results. No information about the test substance purity.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1952
Report Date:
1952

Materials and methods

GLP compliance:
no
Test type:
other: comparison of vapors evolved from the solid at room temperature and at 170°C

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Vehicle:
other: no
No. of animals per sex per dose:
6

Results and discussion

Other findings:
Six rats were exposed, in a 9 liter chamber, to air that had been passed at 2.5 liters per minute through a 100 ml burette loosely packed with 50 grams of p-t-butyl catechol and glass wool. None of the rats died as the result of an 8-hour exposure.

A mist, prepared by heating 50 grams of the compound to 170°C in a gas-washing bottle while air was passed through the fritted glass disc immersed therein, was lethal to 6 rats exposed for 1 hour while only 1 of 6 died in a similar 30-minute exposure. This compound is a solid at room temperature, but after heating at 170°C for 30 minutes it becomes and remains a viscous dark liquid at room temperature.

Applicant's summary and conclusion

Conclusions:
Vapors evolved at room temperature would not be hazardous but the vapor and aerosol produced by heating is definitely hazardous to life.