Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 210-431-8 | CAS number: 615-50-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with Section 1, subsection 1.3 of REACH Annex XI, Qualitative or Quantitative structure-activity relationship (Q)SAR)), hydrolysis as a function of pH does not need to be conducted as the substance is unlikely to undergo hydrolysis. Aromatic amines are resistant to hydrolysis.
Key value for chemical safety assessment
Additional information
Aromatic amines are resistant to hydrolysis (Harris, 1990; Solomons, 1980). Hydrolysis reactions are typically nucleophilic addition or substitutions reactions whereby water acts as the nucleophile and the substance as the electrophile. Amines typically react either as bases or as nucleophiles in alkylation/acylation reactions. The substance is an aromatic amine and cannot behave as an electrophile unless it is metabolically activated. It ionises in water rather than covalently reacts with water. This is further supported by the lack of aromatic amine functional groups or fragments in HYDROWIN 2.0 (EPISuite, US EPA 2008) and by the probable absence of enzymatic hydrolysis reactions (Catalogic 5.10.7, LMC 2009). Based on an understanding of the chemistry of this substance and the existing structure-activity relationships available within the expert systems cited, hydrolysis is not expected to be a relevant degradation mechanism for this substance.
On 2004, the hydrolytic stability of 2-methyl-p-phenylenediamine sulfate was determined according to OECD-Guideline 111. The study was conducted with a test substance concentration of 5 mg/L in buffer solutions of pH 4, 7, and 9 at temperatures of 20, 30, and 50 degrees C. The test substance was found to degradate at pH 4, 7, and 9, at 20, 30, and 50 degrees C. The test substance was considered as hydrolytically unstable.
Based on the structure of this substance and today’s understanding of this class of chemicals, aromatic amines are resistant to hydrolysis. Therefore, the reaction rate constants do not reflect hydrolysis but an oxidative reaction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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