Registration Dossier
Registration Dossier
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EC number: 214-787-5 | CAS number: 1194-65-6
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8 September 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- GLP compliance:
- yes
- Dissociating properties:
- no
- Conclusions:
- Under the conditions of the study, the test material was observed not to dissociate in a dissociation constant study.
- Executive summary:
In a GLP compliant dissociation constant study conducted in accordance with standardised guideline OECD 112, the dissociation constant of the test material was investigated. Under the conditions of the study, the test material was not observed to dissociate.
Reference
No significant differences were exhibited in spectra obtained over the 200-400 nm wavelength at 20 ± 1 ºC in 40 % v/v ethanol/water solutions of 1 x 10-4 M test material prepared at pHs 2.1, 4.0, 6.1, 8.0, 10.1 and 12.1.
Description of key information
No dissociation of the test material was observed according to a study performed in line with OECD Guideline 112.
Key value for chemical safety assessment
Additional information
The key study (Malinksi, 1999) was performed in line with GLP and a standardised guideline with a sufficient level of detail to assess the quality of the study. The study was performed to a good standard and was assigned a reliability score of 1 using the principle for assessing data quality as set out in Klimisch (1997).
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