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EC number: 417-220-1 | CAS number: 37441-29-5 ATIPACL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 (oral) > 2000 mg/kg bw
LD50 (dermal) > 2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity
In the key study the test substance was evaluated for acute oral toxicity in Sprague Dawley male/female rats according to OECD Guideline No. 401. The test substance was administered by oral gavage as a single dose of 2000 mg/kg.
The animals were observed for clinical signs of toxicity and mortality. Examination occurred 15 min after intubation, then at 1, 2 and 4h then each day for 14 days.
No clinical signs or mortality was observed. The animal body weight had a normal evaluation. No gross pathological changes were observed on euthanisied animals.
The LD50, by the oral route, in the rat (male+female) > 2000 mg/kg bw.
In the supporting study the test substance was evaluated for acute oral toxicity in male/female rats according to EU Method B1.
The substance was administered to groups of 5 animals per sex by oral administration at the dose of 2000 mg/kg. The animals were observed for clinical signs of toxicity and mortality. No mortality was observed.
No clinical signs of toxicity were observed that were considered to be related to treatment in any of the animals. Alopecia and/or scubs were observed on the head of 2 males during the 2nd week of the study period. A macroscopic post mortem examination of the animals at termination did not reveal abnormalities.
The LD50 > 2000 mg/kg bw.
Acute dermal toxicity
In the key study the acute dermal toxicity of the test item was evaluated in an experimental study according to OECD Guideline No. 402 and EU Method B.3.
The substance was administered to five rats of each sex by dermal application at 2000 mglkg body weight for 24 hours. Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed at the end of the experimental period (day 15).
No mortality occurred. Lethargy and/or hunched posture were observed in two males on days 2 and 3. Yellow discolouration o f the treated skin area was seen in all animals on day 2.
Body weight gain during the observation period was within the range expected for rats used in this type of study. No abnormalities were found in the animals at macroscopic post mortem examination.
The dermal LD50 value of the test item in rats was established > 2000 mg/kg body weight.
Justification for classification or non-classification
According to the CLP Regulation (EC 1272/2008), classification for acute toxicity by oral and dermal route is required below the threshold value of 2000 mg/kg bw.
Based on available data the test substance is not classified for acute oral or dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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