Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-989-5 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is rated a "1" because it applied GLP and used appropriate testing procedures.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Phthalate Ester Testing in the National Toxicology Program's Environmental Mutagenesis Test Development Program
- Author:
- Zeiger E, et al
- Year:
- 1 982
- Bibliographic source:
- Environ Health Perspect 45:99-101
- Reference Type:
- publication
- Title:
- Mutagenicity Testing of di(2-ethylhexyl) Phthalate and Related Chemicals in Salmonella
- Author:
- Zeiger E, et al
- Year:
- 1 985
- Bibliographic source:
- Environ Mutagen 7(2):213-232
Materials and methods
- Principles of method if other than guideline:
- Method: other: Ames BN et al. Mutat Res. 31:347-364.
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Di-''isodecyl'' phthalate
- EC Number:
- 247-977-1
- EC Name:
- Di-''isodecyl'' phthalate
- Cas Number:
- 26761-40-0
- Molecular formula:
- C28H46O4
- IUPAC Name:
- 1,2-benzenedicarboxylic acid, di-isodecyl ester
- Details on test material:
- IUCLID4 Test substance: other TS: DIDP with different CAS#
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- homogenates of Aroclor 1254-induced Sprague-Dawley rat and Syrian hamster liver S9
- Test concentrations with justification for top dose:
- from 100 up to 10,000 ug/plate
- Vehicle / solvent:
- 95% ethanol
- Details on test system and experimental conditions:
- IUCLID4 Type: Ames test
- Evaluation criteria:
- A positive mutagenic response was defined as a reproducible, dose-related increase in his+ revertants over spontaneous level
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: other: Salmonella strains TA98, TA100, TA1535, TA1537
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- The test substance was not mutagenic in the preincubation modification of the Salmonella microsome test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
