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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Experiment conducted to specifically determine the melting temperature of AHTN. The experiment is conducted in-house at PFW (non-GLP).
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
no
Type of method:
capillary method
Melting / freezing pt.:
55.1 °C
Atm. press.:
1 atm
Decomposition:
no
Sublimation:
no
Remarks on result:
other: at 98.0% AHTN concentration in Tonalid
Melting / freezing pt.:
54.5 °C
Atm. press.:
1 atm
Decomposition:
no
Sublimation:
no
Remarks on result:
other: at 97.0% AHTN concentration in Tonalid

A linear relationship exists between the melting point and the purity of the active substance concentration in Tonalid).

Conclusions:
The melting point of the substance is 54 °C.
Executive summary:

A relationship between the melting point of Tonalid and the AHTN concentration in Tonalid was established. The AHTN concentration was determined with gas chromatography and the melting temperaturature with the capillary method.

Description of key information

Melting point depends on the purity of the material and ranges from 54°C to 56°C 97.0-99.2%, tested according to the EU method A.1 guideline.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
54 °C

Additional information

Determination of the melting point is a standard quality control parameter. The test item concentration was determined with gas chromatography and the melting temperature with the capillary method. The melting point is linear related with the purity varying from 54 °C to 56 °C in the range of 97.0% to 99.2% of the test item.