Registration Dossier
Registration Dossier
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EC number: 249-922-7 | CAS number: 29878-91-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Safepharm Standard Test Method M26
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Method of Ames et. al.
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 1,1'-binaphthyl-8,8'-dicarboxylic acid
- EC Number:
- 249-922-7
- EC Name:
- 1,1'-binaphthyl-8,8'-dicarboxylic acid
- Cas Number:
- 29878-91-9
- Molecular formula:
- C22H14O4
- IUPAC Name:
- [1,1'-binaphthalene]-8,8'-dicarboxylic acid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- S-9 Liver microson mix
- Test concentrations with justification for top dose:
- 20-12,500 µg/plate
- Vehicle / solvent:
- DMSO
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- at dose levels of 2,500-12,500 µg/Plate toxicity was observed, resulting in a kill of the background lawn.
- Vehicle controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- The test substance was found to be not mutagenic in the AMES-Test
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