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Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
7th November 2001 and 26th November 2001
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report date:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. QA statement)
Remarks:
UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106))

Test material

Constituent 1
Chemical structure
Reference substance name:
(1R, 4R, 5S) 4-hydroxy-6,6-dimethyl-3-Oxabicyclo[3.1.0]hexan-2-one
EC Number:
619-753-7
Cas Number:
73611-02-6
Molecular formula:
C7H10O3
IUPAC Name:
(1R, 4R, 5S) 4-hydroxy-6,6-dimethyl-3-Oxabicyclo[3.1.0]hexan-2-one

Study design

Duration of testopen allclose all
Duration:
5 d
pH:
4
Initial conc. measured:
1 g/L
Duration:
5 d
pH:
7
Initial conc. measured:
1 g/L
Duration:
5 d
pH:
9
Initial conc. measured:
1 g/L

Results and discussion

Transformation products:
not measured
Dissipation DT50 of parent compoundopen allclose all
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
pH:
9
Temp.:
25 °C
DT50:
> 1 yr

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Hydrolysis halflife is greater than 1 year at 25 °C