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EC number: 604-569-1
CAS number: 147126-62-3
In these experiments a near-saturated solution of OSME in water
containing 1% acetonitrile was diluted (1/1 v/v) in pH 4, pH 7, and pH 9
buffer solutions, also containing 1% acetonitrile co-solvent. Either no
OSME or traces of OSME were detected by HPLC in these buffer solutions.
The pH 9 solution showed the presence of presumably the acid hydrolysis
product of OSME, whereas this was essentially absent in the pH 4 and pH
7 solutions. in another experiment it was confirmed that the hydrolysis
of OSME was relatively minor in pH 4 buffer / acetonitrile solutions
compared to pH 9 buffer / acetonitrile solutions over a period of 6 h at
~ 22 °C. This was consistent with the general observation that the
hydrolysis of carboxylic acid esters is faster under basic conditions
than under acid conditions (Mabey, 1978).
lt should be noted that homogeneaus conditions are required for the
accurate determination of the hydrolysis rate. The observed adsorption
of OSME would introduce a heterogeneaus component to the hydrolysis
reaction which would likely reduce the hydrolysis rate by effectively
lowering the concentration of OSME in solution. Therefore, given that
the OECD hydrolysis test allows a maximum of 1% organic cosolvent (OECD
Guideline 111, 1993), it was judged that the extensive adsorption of
OSME observed at this low co-solvent concentration would introduce
unacceptable error into the OECD hydrolysis test results. The OECD
hydrolysis test was, therefore, not conducted.
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