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Diss Factsheets
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EC number: 939-267-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation
Reliable in vivo skin irritation studies described in Kukulinski (2011 & 2012) conducted on the three Borate Cobalt carboxylates (OECD 404 (modified), GLP compliant) are considered to be reliable without restrictions. As Cobalt(2+) Borate C3/C8/C10 carboxylates salts composition is a combination of the 3 cobalt borate carboxylates complexes tested for skin, conclusions of absence of irritation in the 3 compounds can thus be used to conclude in a similar way for the Cobalt(2+) Borate C3/C8/C10 carboxylates salts.
Eye irritation
Three reliable in vitro studies described by Heppenheimer conducted on the three Borate Cobalt carboxylates (OECD 437; GLP compliant) are considered to be reliable without restrictions. The threshold of the mean in vitro irritation score for corrosivity / severe irritancy is a score equal or higher than 55.1. All of the three eye irritation scores are clearly below this threshold.
Three reliable in vivo studies described by Sanders conducted on the three Borate Cobalt carboxylates (OECD 405; GLP compliant) are considered to be reliable without restrictions. The Cobalt borate 2-ethylhexanoate and Cobalt borate neodecanoate were determined to cause irritating effects on the eye whereas Cobalt borate propionate was determined to be severely irritating to the eye. As a worst case approach, Cobalt(2+) Borate C3/C8/C10 carboxylates salts can thus be considered as severely irritating to the eye.
Effects on eye irritation: corrosive
Justification for classification or non-classification
Skin irritation
References Kukulinski are the key studies for in vivo skin irritation and will be used for classification. The skin irritation was scored according to the Draize scale. The mean score (24, 48, 72h) for erythema and oedema was 0 for all animals. The studies were terminated after the 72 hour observation. According to regulation (EC) 1272/2008 and subsequent amendments the substance does not need to be classified as skin irritant.
Eye irritation
Cobalt borate 2-ethylhexanoate produced mild iridial inflammation, moderate conjunctival irritation and diffuse corneal opacity; the effects were fully reversible within 21 days. Cobalt borate neodecanoate produced conjunctival redness at the threshold of ≥ 2 as well as reversible effects within 14 days. The classification criteria according to regulation (EC) 1272/2008 as irritating to the eye are met (Category 2) for both substances.
Cobalt borate propionate showed severe irritating effects in cornea, iris and conjunctivae. The classification criteria according to regulation (EC) 1272/2008 as severe eye irritation are met., hence the substance will be classified as severe eye irritant (Category 1, R41).
Thus, as a worst case approach, the Salt reaction of borate, cobalt(2+) and C3/C8/C10 carboxylates will be classified as severe eye irritant (Category 1) according to regulation (EC) 1272/2008.
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