Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-486-0 | CAS number: 102687-65-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- other: "Method for Testing the Partition Coefficient (n-octanolfwater)" in the "Testing Methods for New Chemical Substances" (Japan)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. 2.2
- Temp.:
- 25 °C
- pH:
- ca. 7.4
- Conclusions:
- The substance has a log Kow of 2.2.
- Executive summary:
The partitioning coefficient octanol-water (Kow) of the substance was determined in a study in accordance with OECD TG 117 (HPLC method) and in compliance with GLP criteria (Kurume Laboratory, 2009). In this study, the retention time of the test item in a HPLC with a 'L-column ODS' column was compared to retention times of reference substances with known log Kow. From the results, a log Kow of 2.2 was determined for the test substance.
Reference
Measurement results:
Name |
tR |
k |
Log k |
Log Kow |
|
Reference items |
Thiourea (for dead time; t0) |
1.97 |
Average t0= 1.97 |
||
1.97 |
|||||
Acetanilide |
3.00 |
0.523 |
-0.282 |
1.0 |
|
3.00 |
0.523 |
-0.282 |
1.0 |
||
Acetophenone |
4.37 |
1.218 |
0.086 |
1.7 |
|
4.37 |
1.218 |
0.086 |
1.7 |
||
Methyl benzoate |
7.17 |
2.640 |
0.422 |
2.1 |
|
7.17 |
2.640 |
0.422 |
2.1 |
||
Trichloroethylene |
12.50 |
5.345 |
0.728 |
2.4 |
|
12.50 |
5.345 |
0.728 |
2.4 |
||
Allyl phenyl ether |
15.25 |
6.741 |
0.829 |
2.9 |
|
15.25 |
6.741 |
0.829 |
2.9 |
||
Bromobenzene |
17.40 |
7.832 |
0.894 |
3.0 |
|
17.38 |
7.822 |
0.893 |
3.0 |
||
Test item |
HFO-1233zd(trans) |
7.40 |
2.756 |
0.440 |
2.2 |
7.40 |
2.756 |
0.440 |
2.2 |
||
Description of key information
A log Kow of 2.2 was determined for the test substance.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.2
- at the temperature of:
- 25 °C
Additional information
The partitioning coefficient octanol-water (Kow) of the substance was determined in a study in accordance with OECD TG 117 (HPLC method) and in compliance with GLP criteria (Kurume Laboratory, 2009). In this study, the retention time of the test item in a HPLC with a 'L-column ODS' column was compared to retention times of reference substances with known log Kow.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
