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EC number: 239-311-3
CAS number: 15267-95-5
TEST ATMOSPHERE CONDITIONS
Temperature, relative humidity and oxygen
concentration during exposure were considered to be
satisfactory for this type of study.
Tab. 1: Data
on temperature, relative humidity and oxygen concentration
CHEMICAL DETERMINATION OF VAPOR
Details on chemically determined vapor concentrations
Amount of Test Item in
the Solvent Trap
A group of three male and three female
albino rats [RccHanTM:WIST(SPF)] was exposed by nose-only, flow-past
vapor inhalation for four hours to the test item at a chemically
determined mean concentration of 4.7 mg/l air. All animals were observed
for clinical signs and mortality during the inhalation exposure and the
subsequent 14-day observation period. Body weights were recorded prior
to exposure on test day 1, and during the observation period on test
days 2, 4, 8 and 15 before necropsy. On test day 15 all animals were
sacrificed and necropsied. The vapor concentration, temperature,
relative humidity, oxygen content and airflow rate measured during the
exposure were considered to be satisfactory for a study of this type. In
addition, as a vapor the test item was considered to be respirable to
rats. All animals survived the scheduled observation period. Most
animals showed salivation and reddish nasal secretion during exposure
and ruffled fur, decreased activity and hunched posture thereafter.
There were no clinical signs recorded from test day 2 onwards. From test
day 1 to test day 2, slight body weight loss was noted in all animals.
Thereafter normal body weight development was recorded. No macroscopic
findings were present at necropsy. In conclusion, the LC50 for 4-hour
exposure of (chloromethyl)triethoxysilane obtained in this study was
greater than 4.7 mg/l air (chemically determined mean vapor
concentration). This concentration was at the technical limit for a
vapor and considered to be close to the saturation concentration. There
was no indication of relevant sex-related differences in toxicity of the
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